We offer inhibitor profiling in living cells using the NanoBRET platform by Promega. We believe that a cellular characterization is necessary to understand the cellular effect of your inhibitor. We offer assessments on selectivity across the kinome, inhibitor EC50 determination and follow-up half-life analysis. We also address HDACs and BRDs in the field of epigenetics and E3-ligases in the emerging field of PROTACS. So let's illuminate science together!
Test your small molecule across a representative fraction of the kinome in living cells!
We determine a 10-point Dose-response for your combination of kinase and compound!
We determine a 10-point Dose-response for your combination of E3 and compound!
We determine the half-live of your compound in a wash-out experiment at 10x EC50!
We are experienced scientists with 8+ years of involvement into various inhibitor development projects in the field of kinases, bromodomains, E3s and HDACs. We experienced a rising number of requests from the field to get cellular target engagement data on the small molecules of interest and to address that, founded CELLinib in 2021. We are dedicated to deliver your data with speed and accuracy. Please feel free to contact us if you are interested in our services!
Dr. Benedict-Tilman Berger was born in 1991 in Berlin, Germany. He studied Biochemistry at the Freie University Berlin where he received his Bachelor (2014) and Master (2016) of Science. During his st...
Lena Marie Berger was born in 1995 in Essen, Germany. She studied Biology at the Freie University Berlin where she received her Bachelor of Science in 2016. During her Bachelor’s she worked in t...
Please contact us if you are interested in our services!